Scientific publications

• Neuromuscular transmission deficits in patients with CMT and ClC-1 inhibition in CMT animal models

• Annals of Clinical and Translational Neurology, 13 December 2024

• Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial

• ASCPT Clinical Pharmacology and Therapeutics, 9 December 2024

• ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

• Nature Communications, 28 October 2024

  The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis

• Science Translational Medicine, March 2024

• Role of recovery of acetylcholine release in compromised neuromuscular junction function

• Neuromuscular Disorders, March 2024

• Six weeks of high-load resistance and low-load blood flow restricted training increase Na/K-ATPase sub-units α2 and β1 equally, but does not alter ClC-1 abundance in untrained human skeletal muscle

• Journal of Muscle Research and Cell Motility, April 2023

• Alterations in fast-twitch muscle membrane conductance regulation do not explain decreased muscle function of SOD1G93A rats

• Muscle & Nerve, Sep. 2021

• Chloride channel inhibition improves neuromuscular function under conditions mimicking neuromuscular disorders

• Acta Physiologica, May 2021

• Depletion of ATP Limits Membrane Excitability of Skeletal Muscle by Increasing Both ClC1-Open Probability and Membrane Conductance

• Journal of General Physiology, June 2020

• Chloride Channels Take Center Stage in Acute Regulation of Excitability in Skeletal Muscle: Implications for Fatigue

  • Physiology (Bethesda), Nov. 2017

  • Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle

  • Journal of General Physiology, April 2016

  • Protein kinase C-dependent regulation of ClC-1 channels in active human muscle and its effect on fast and slow gating

  • Journal of General Physiology, June 2016

  • Determination of cable parameters in skeletal muscle fibres during repetitive firing of action potentials

  • Journal of General Physiology, Oct. 2014

  • Relationship between membrane Cl- conductance and contractile endurance in isolated rat muscles

  • Journal of General Physiology, Jan. 2013

  • Lactate per se improves the excitability of depolarized rat skeletal muscle by reducing the Cl- conductance

  • Journal of General Physiology, Dec. 2010

  • Regulation of ClC-1 and KATP channels in action potential-firing fast-twitch muscle fibers

  • Journal of General Physiology, Oct. 2009

  • Comparison of regulated passive membrane conductance in action potential-firing fast- and slow-twitch muscle

  • Journal of General Physiology, Oct. 2009

  • Increased excitability of acidified skeletal muscle: role of chloride conductance

  • Journal of General Physiology, Feb. 2005

  • Intracellular acidosis enhances the excitability of working muscle

  • Science, Aug. 2004